Sodium Hydroxide → 2-Methoxy-1,3-thiazole-5-carboxylic acid

HRID 1480388ノート

反応式

HRID 1480388 の反応式
Cl[C:2]1[S:3][C:4]([C:7]([O:9]C(C)(C)C)=[O:8])=[CH:5][N:6]=1.[CH3:14][O-:15].[Na+].[OH-].[Na+]>CC#N.CO>[CH3:14][O:15][C:2]1[S:3][C:4]([C:7]([OH:9])=[O:8])=[CH:5][N:6]=1

参加物

6

反応物 3

HCID 14798Sodium HydroxideHCID 10942334Sodium MethoxideHCID 24229786tert-Butyl 2-chloro-1,3-thiazole-5-carboxylate

生成物 1

HCID 164948972-Methoxy-1,3-thiazole-5-carboxylic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒2 回HCID 6342Acetonitrile溶媒

反応条件

温度
80 °C

実験手順

To a solution of tert-butyl 2-chlorothiazole-5-carboxylate (100 mg, 0.455 mmol) in MeCN (880 μl) and MeOH (880 ul) was added 5.4M NaOMe in MeOH (337 μl, 1.821 mmol) followed by 2M NaOH (881 μl, 1.762 mmol). The reaction mixture was heated to 80° C. overnight and, after cooling to RT, the mixture was evaporated under reduced pressure. The residue was acidified with a minimal volume of 6M aqueous hydrochloric acid. The resulting precipitate was filtered, washed with water and dried in a high vacuum oven overnight to afford the title compound;

後処理

  1. temperatureafter cooling to RT
  2. customthe mixture was evaporated under reduced pressure
  3. filtrationThe resulting precipitate was filtered
  4. washwashed with water
  5. customdried in a high vacuum oven overnight

出典と根拠

ORDレコード
ord-d54a00cbb60c4c57bb0975f2edfc08d4
出典データセット
uspto-grants-2016_08
特許番号
US09409895B2

反応ノート

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