Sodium Hydroxide → 3-(3,5-Dichlorophenyl)acrylic acid
反応式
[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([O:13]C)=[O:12])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[OH-].[Na+]>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([OH:13])=[O:12])[CH:5]=[C:6]([Cl:8])[CH:7]=1参加物
4
実験手順
To (E)-methyl 3-(3,5-dichlorophenyl)acrylate (step 1) (2 g, 8.66 mmol) in THF (35 ml) was added 2M NaOH (12.98 ml, 26.0 mmol) and the reaction mixture was stirred at RT overnight. The solvent was removed under reduced pressure and the residue was dissolved in water and washed with EtOAc. The aqueous portion was acidified to pH 4 using 1M HCl and extracted with DCM. The organic portion was dried using a phase separating column and the solvent removed under reduced pressure to afford the title compound as a white solid;
後処理
- customThe solvent was removed under reduced pressure
- dissolutionthe residue was dissolved in water
- washwashed with EtOAc
- extractionextracted with DCM
- customThe organic portion was dried
- customseparating column
- customthe solvent removed under reduced pressure
出典と根拠
- ORDレコード
- ord-caab693769ac4e62b8ba72e0eb1f1095
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09409895B2
反応ノート
読み込み中…