N,N-dimethyl-4-nitrobenzenesulfonamide → Benzenesulfonamide, 4-amino-N,N-dimethyl-

HRID 1484832

反応式

HRID 1484832 の反応式
[CH3:1][N:2]([CH3:15])[S:3]([C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][CH:7]=1)(=[O:5])=[O:4]>CO.[Pd]>[NH2:12][C:9]1[CH:10]=[CH:11][C:6]([S:3]([N:2]([CH3:15])[CH3:1])(=[O:5])=[O:4])=[CH:7][CH:8]=1

参加物

4

反応物 1

HCID 2747580N,N-dimethyl-4-nitrobenzenesulfonamide

生成物 1

HCID 74369Benzenesulfonamide, 4-amino-N,N-dimethyl-収率 95%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Under H2, N,N-dimethyl-4-nitrobenzenesulfonamide (879 mg, 3.8 mmol, 1.0 equiv.) was catalytically hydrogenated in the presence of Pd/C (40 mg) in MeOH (25 mL). When no more H2 was consumed, the reaction mixture was filtered. The filtrate was concentrated and crystallized to afford compound 4-amino-N,N-dimethyl benzenesulfonamide (722 mg, 95%).

後処理

  1. customWhen no more H2 was consumed
  2. filtrationthe reaction mixture was filtered
  3. concentrationThe filtrate was concentrated
  4. customcrystallized

出典と根拠

ORDレコード
ord-516b0c9b1bff4851872f7983c660b89c
出典データセット
uspto-grants-2016_08
特許番号
US09422271B2

関連ノート

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