Triethylamine → Pyrrolidine-1-carboximidamide hydrochloride

HRID 1488074ノート

反応式

HRID 1488074 の反応式
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[ClH:13].[N:14]1([C:19](=N)[NH2:20])C=CC=N1>CC#N>[ClH:13].[N:1]1([C:19](=[NH:14])[NH2:20])[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31268PyrrolidineHCID 2734672Pyrazole-1-carboxamidine monohydrochloride

生成物 1

HCID 13221241Pyrrolidine-1-carboximidamide hydrochloride収率 72%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
60 °C

実験手順

Into a 100-mL round-bottom flask, was placed a solution of pyrrolidine (5.8 mL, 70.30 mmol) in CH3CN (30 mL). Triethylamine (9.8 mL, 70.17 mmol) and 1H-pyrazole-1-carboximidamide hydrochloride (10.2 g, 69.59 mmol) was added to the reaction. The reaction mixture was stirred overnight at 60° C. The product was collected by filtration to yield 7.5 g (71%) of the title compound as a white solid.

後処理

  1. customInto a 100-mL round-bottom flask, was placed
  2. filtrationThe product was collected by filtration

出典と根拠

ORDレコード
ord-4e56b6b75857492abb1472fcca655b68
出典データセット
uspto-grants-2016_08
特許番号
US09428502B2

反応ノート

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