1-Methyl-2,3-dihydro-1H-indole → 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indole
反応式
CN1CCc2ccccc21>B1Oc2ccccc2O1.C1=CC2C=CC1C2.CC(C)(O)C(C)(C)O.CCN(CC)CC.Cc1ccccc1.Fc1c(F)c(F)c(B(c2c(F)c(F)c(F)c(F)c2F)c2c(F)c(F)c(F)c(F)c2F)c(F)c1F>CN1CCc2cc(B3OC(C)(C)C(C)(C)O3)ccc21参加物
8
反応物 1
生成物 1
試薬・触媒・溶媒 6
反応条件
- 温度
- 25 °C
実験手順
Prepared from 1-methylindoline (1j, 13.5 mg, 0.100 mmol, 1.00 equiv), catBH (24.0 mg, 0.200 mmol, 2.00 equiv), norbornadiene (9.2 mg, 0.10 mmol, 1.00 equiv) and B(C6F5)3 (5.1 mg, 0.010 mmol, 0.10 equiv) according to GP 3. The title compound was purified by flash column chromatography using cyclohexane/EtOAc/Et3N (30/1/1) as eluent to afford 3j (7.5 mg, 30%) as a white solid.
出典と根拠
- ORDレコード
- ord-a69ae003920743bcb48cb3ac16966ce5
- 出典データセット
- Borylation dataset from Roche
反応ノート
読み込み中…