2-Methyl-7-(trifluoromethyl)quinoline → HCID 178422399、化合物

HRID 1490913

反応式

HRID 1490913 の反応式
Cc1ccc2ccc(C(F)(F)F)cc2n1>C1=CCCC=CCC1.C1=CCCC=CCC1.CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(C)(C)C.C[OH2+].C[OH2+].[Ir].[Ir]>Cc1cc(B2OC(C)(C)C(C)(C)O2)c2ccc(C(F)(F)F)cc2n1.Cc1ccc2c(B3OC(C)(C)C(C)(C)O3)cc(C(F)(F)F)cc2n1

参加物

7

反応物 1

HCID 224169042-Methyl-7-(trifluoromethyl)quinoline

生成物 2

HCID 178422399HCID 178422399、化合物収率 57%HCID 178422497HCID 178422497、化合物収率 38%

試薬・触媒・溶媒 4

HCID 2733548Bis(pinacolato)diborane試薬HCID 42491874,4'-Di-tert-butyl-2,2'-bipyridyl試薬HCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridium触媒HCID 15413tert-Butyl methyl ether溶媒

反応条件

温度
100 °C

実験手順

Application of general procedure A to 2-methyl-7-(trifluoromethyl)quinoline (211 mg, 1.00mmol) afforded 2 monoborylated products as a 60:40 ratio.

出典と根拠

ORDレコード
ord-297c3aeb46f14a219f8a39f08fe03a57
出典データセット
Borylation dataset from Roche

関連ノート

読み込み中…