N-Methylbenzamide → N-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

HRID 1491051ノート

反応式

HRID 1491051 の反応式
CNC(=O)c1ccccc1>C1=CCCC=CCC1.C1=CCCC=CCC1.C1CCOC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.C[OH2+].C[OH2+].Cc1[nH]c2c(NC(=O)c3ccc(-c4ccccn4)nc3)cccc2c1C.[Ir].[Ir]>CNC(=O)c1ccccc1B1OC(C)(C)C(C)(C)O1

参加物

6

反応物 1

HCID 11954N-Methylbenzamide

生成物 1

HCID 69218561N-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide収率 63%

試薬・触媒・溶媒 4

HCID 2733548Bis(pinacolato)diborane試薬HCID 178433626HCID 178433626、化合物試薬HCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridium触媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
60 °C

実験手順

Isolated by chromatography using deactivated silica gel and ethyl acetate and petroleum ether (10:1 to 2:1) as the eluent.

出典と根拠

ORDレコード
ord-c18ad94aa18f45c0aaae4d5010cc96ea
出典データセット
Borylation dataset from Roche

反応ノート

読み込み中…