N-Boc-4-hydroxyaniline → Tert-butyl (4-hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)carbamate

HRID 1491233ノート

反応式

HRID 1491233 の反応式
CC(C)(C)OC(=O)Nc1ccc(O)cc1>C1=CCCC=CCC1.C1=CCCC=CCC1.CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CC1(C)OBOC1(C)C.COC(C)(C)C.C[OH2+].C[OH2+].[Ir].[Ir]>CC(C)(C)OC(=O)Nc1ccc(O)cc1B1OC(C)(C)C(C)(C)O1

参加物

7

反応物 1

HCID 2756771N-Boc-4-hydroxyaniline

生成物 1

HCID 71742938Tert-butyl (4-hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)carbamate収率 78%

試薬・触媒・溶媒 5

HCID 2733548Bis(pinacolato)diborane試薬HCID 27347684,4,5,5-Tetramethyl[1,3,2]dioxaborolane試薬HCID 42491874,4'-Di-tert-butyl-2,2'-bipyridyl試薬HCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridium触媒HCID 15413tert-Butyl methyl ether溶媒

反応条件

温度
50 °C

出典と根拠

ORDレコード
ord-1139608af0de453f8fc0d7e140ea28b2
出典データセット
Borylation dataset from Roche

反応ノート

読み込み中…