Trifluoroacetic acid → 1-propylcyclopropanecarboxylic acid
反応式
[CH2:1]([C:4]1([C:7]([O:9]C(C)(C)C)=[O:8])[CH2:6][CH2:5]1)[CH2:2][CH3:3].FC(F)(F)C(O)=O>[OH-].[Na+]>[CH2:1]([C:4]1([C:7]([OH:9])=[O:8])[CH2:6][CH2:5]1)[CH2:2][CH3:3]参加物
4
実験手順
A stirred mixture of 21.0 g (0.11 mol) of tertbutyl 1-n-propylcyclopropanecarboxylate and 13.0 g (0.11 mol) of trifluoroacetic acid was refluxed for 3 hours and then added to 20 ml of dilute sodium hydroxide solution. After extraction of the byproducts with diethyl ether, the aqueous phase was acidified with dilute hydrochloric acid and again extracted with diethyl ether. This ether phase was then worked up in a conventional manner to obtain the product. Yield: 95%; colorless oil.
後処理
- temperaturewas refluxed for 3 hours
- extractionAfter extraction of the byproducts with diethyl ether
- extractionagain extracted with diethyl ether
- customto obtain the product
出典と根拠
- ORDレコード
- ord-b24aaf9051bb420dafbdcd20225dd42e
- 出典データセット
- uspto-grants-1994_12
- 特許番号
- US05371268
反応ノート
読み込み中…