Allyl bromide → 4-Allyloxy-3-allylbenzoic acid methyl ester

HRID 1492601

反応式

HRID 1492601 の反応式
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[CH2:12][CH:13]=[CH2:14].C(=O)([O-])[O-].[K+].[K+].[CH2:21](Br)[CH:22]=[CH2:23]>CC(C)=O>[CH2:12]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:2]=1[O:1][CH2:23][CH:22]=[CH2:21])[C:6]([O:8][CH3:9])=[O:7])[CH:13]=[CH2:14]

参加物

5

反応物 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 939882Methyl 3-allyl-4-hydroxybenzoate

生成物 1

HCID 112417484-Allyloxy-3-allylbenzoic acid methyl ester収率 87%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A solution of 3.04 g (15.8 mmol) of methyl 4-hydroxy-3-propenylbenzoate (Example 7, Step B) was refluxed with anhydrous potassium carbonate (4.37 g, 2 equiv) and allyl bromide (3.5 mL. 2.5 equiv) in acetone overnight. The mixture was filtered through celite and the filter cake was washed with more acetone and dichloromethane. After removing the solvents, the resulting oil was distilled under high vacuum to give 3.2 g (87%) of the title compound.

後処理

  1. filtrationThe mixture was filtered through celite
  2. washthe filter cake was washed with more acetone and dichloromethane
  3. customAfter removing the solvents
  4. distillationthe resulting oil was distilled under high vacuum

出典と根拠

ORDレコード
ord-a9313012b2f845a988c69a43cfbde043
出典データセット
uspto-grants-1994_12
特許番号
US05374638

関連ノート

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