Thiophenol → 1-Propanone, 2-methyl-1-phenyl-2-(phenylthio)-

HRID 1494437

反応式

HRID 1494437 の反応式
[H-].[Na+].[C:3]1([SH:9])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl[C:11]([CH3:21])([CH3:20])[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:13]>CN(C=O)C>[C:3]1([S:9][C:11]([CH3:21])([CH3:20])[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:13])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 7969ThiophenolHCID 24758Sodium hydrideHCID 819851-Propanone, 2-chloro-2-methyl-1-phenyl-

生成物 1

HCID 122705891-Propanone, 2-methyl-1-phenyl-2-(phenylthio)-

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
2 °C

実験手順

10.88 g of a 50% suspension of sodium hydride in paraffin mineral oil are fed into 100 ml of DMF, followed slowly by 25.11 g of thiophenol. When dissolution is complete (65° C.), the solution is cooled to 2° C. and 36.5 g of 2-chloro-2-methylpropiophenone are fed in over 30 minutes maintaining the temperature below 10° C.

後処理

  1. dissolutionWhen dissolution
  2. custom(65° C.)
  3. customare fed in over 30 minutes
  4. temperaturemaintaining the temperature below 10° C.

出典と根拠

ORDレコード
ord-5752ad7ba6814d479c4aac8bf2293d7c
出典データセット
uspto-grants-1991_06
特許番号
US05026740

関連ノート

読み込み中…