Chlorotrimethylsilane → HCID 178462437、化合物

HRID 1498832ノート

反応式

HRID 1498832 の反応式
[Zn:1].[Br:2]CCBr.Cl[Si](C)(C)C.Br[CH:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH3:13]>C1COCC1>[Br-:2].[C:14]1([CH:12]([Zn+:1])[CH3:13])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

6

反応物 4

HCID 6397ChlorotrimethylsilaneHCID 78391,2-DibromoethaneHCID 11454(1-Bromoethyl)benzeneHCID 23994Zinc

生成物 1

HCID 178462437HCID 178462437、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a suspension mixture of zinc powder (active, 5.1 g, 80.0 mmol) in dry THF (20 mL) was added dropwise 1,2-dibromoethane (0.28 mL, 5.7 mmol) at 70° C. under nitrogen atmosphere, followed by the addition of chlorotrimethylsilane (1.2 mL, 10.6 mmol). Subsequently, (1-bromoethyl)benzene (3.7 g, 20 mmol) was added dropwise. The resultant suspension was stirred at 70° C. for another 1 h. The reaction mixture was cooled to RT and directly used for the next step.

出典と根拠

ORDレコード
ord-ce6132e4c18f4c558fc8ddc0776c7a96
出典データセット
uspto-grants-2015_12
特許番号
US09200002B2

反応ノート

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