Methyl iodide → 1,3-Difluoro-5-(methylsulfanyl)benzene
反応式
CI.[F:3][C:4]1[CH:5]=[C:6]([SH:11])[CH:7]=[C:8]([F:10])[CH:9]=1.[C:12](=O)([O-])[O-].[K+].[K+]>CC#N>[F:3][C:4]1[CH:5]=[C:6]([S:11][CH3:12])[CH:7]=[C:8]([F:10])[CH:9]=1参加物
5
反応条件
- 温度
- 80 °C
実験手順
Methyl iodide (2.91 g, 20.5 mmol) was added dropwise to a stirred mixture of 3,5-difluorobenzenethiol (2.00 g, 13.7 mmol) and potassium carbonate (5.67 g, 41.0 mmol) in dry MeCN (24 mL) at room temperature. The reaction mixture was stirred at 80° C. for 2 h. After cooling, the mixture was filtered under vacuum, washed with MeCN and concentrated under reduced pressure to give the sub-title compound, which was used directly in the next step without further purification (1.74 g, 80%).
後処理
- temperatureAfter cooling
- filtrationthe mixture was filtered under vacuum
- washwashed with MeCN
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-6a9dd3446c664da4be4cebcf06a12dd7
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09200004B2
反応ノート
読み込み中…