Chloride → 1-Benzyl-5-biphenyl-4-ylmethyl-5-hydroxy-pyrrolidin-2-one

HRID 1500449

反応式

HRID 1500449 の反応式
[CH2:1]([N:8]1[C:12](=[O:13])[CH2:11][CH2:10][C:9]1=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[Cl-].[NH4+].[CH2:18]1[CH2:22]O[CH2:20][CH2:19]1>>[CH2:1]([N:8]1[C:12]([CH2:20][C:19]2[CH:20]=[CH:19][C:18]([C:22]3[CH:6]=[CH:7][CH:2]=[CH:3][CH:4]=3)=[CH:22][CH:18]=2)([OH:13])[CH2:11][CH2:10][C:9]1=[O:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 4

HCID 312ChlorideHCID 8028Tetrahydrofuran2 回HCID 25517Ammonium ChlorideHCID 952411-(Phenylmethyl)-2,5-pyrrolidinedione

生成物 1

HCID 593184651-Benzyl-5-biphenyl-4-ylmethyl-5-hydroxy-pyrrolidin-2-one

反応条件

温度
-78 °C

実験手順

9.5 g N-Benzylsuccinimide is added to 120 ml THF and the mixture is then cooled to −78° C. A solution of 4-methylbiphenylmagnesium chloride in THF (1.3 eq) is then added. The subsequent mixture is then stirred for 2 h at −78° C. The mixture is then warmed to 10° C. and 100 ml saturated ammonium chloride solution is added. The phases are separated and the aqueous phase is extracted with toluene. The combined organic phases are washed with water then brine and then concentrated in vacuo. The crude material is crystallized from toluene to give 1-Benzyl-5-biphenyl-4-ylmethyl-5-hydroxy-pyrrolidin-2-one. 1H NMR (DMSO): 1.72 (1H), 1.91 (1H), 2.27 (2H), 2.72 (1H), 2.97 (2H), 4.40 (1H), 4.55 (1H), 7.21-7.66 (14H).

後処理

  1. temperatureThe mixture is then warmed to 10° C.
  2. customThe phases are separated
  3. extractionthe aqueous phase is extracted with toluene
  4. washThe combined organic phases are washed with water
  5. concentrationbrine and then concentrated in vacuo
  6. customThe crude material is crystallized from toluene

出典と根拠

ORDレコード
ord-cc005ca0e605408ca962755f9bf07add
出典データセット
uspto-grants-2015_12
特許番号
US09206116B2

関連ノート

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