Acetic Acid → HCID 178503516、化合物

HRID 1500455ノート

反応式

HRID 1500455 の反応式
[OH:1][C:2]1[N:7]=[C:6]([SH:8])[N:5]=[C:4]2[NH:9][N:10]=[C:11]([CH3:12])[C:3]=12.[OH-].[Na+].CI.[CH3:17]C(O)=O>O>[OH:1][C:2]1[N:7]=[C:6]([S:8][CH3:17])[N:5]=[C:4]2[NH:9][N:10]=[C:11]([CH3:12])[C:3]=12

参加物

6

反応物 4

HCID 176Acetic AcidHCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 178434482HCID 178434482、化合物

生成物 1

HCID 178503516HCID 178503516、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a mixture of 4-hydroxy-6-mercapto-3-methylpyrazolo[3,4-d]pyrimidine (A-1) (2.86 g, 11.8 mmol) and NaOH (0.8 g, 20 mmol) in water (20 mL) at 5° C., was added CH3I (2.0 g, 14.2 mmol). After stirred at ambient temperature for 30 min, the solution was acidified with HOAc to give the crude product of the title compound (A-2), which used in next step without further purification. MS-ESI (m/z): 197.0 (M+H)+.

出典と根拠

ORDレコード
ord-bdbdf110cbb54d9797f0d4b8d7040e3b
出典データセット
uspto-grants-2015_12
特許番号
US09206166B2

反応ノート

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