HCID 86718001、化合物 → 5-Methyl-2,3-dihydro-1-benzofuran-7-amine

HRID 1500462ノート

反応式

HRID 1500462 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([N+:11]([O-])=O)[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1>C1COCC1.[Pd]>[CH3:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1

参加物

4

反応物 1

HCID 86718001HCID 86718001、化合物

生成物 1

HCID 552848285-Methyl-2,3-dihydro-1-benzofuran-7-amine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 5-methyl-7-nitro-2,3-dihydrobenzofuran (1c) (0.30 g, 1.7 mmol) and Pd/C (150 mg, 50%) in THF (5 mL) was introduced H2. It was stirred at ambient temperature for 12 h. The mixture was filtered through celite and concentrated to give the title compound (1d) as a solid. MS-ESI (m/z): 150 (M+1)+.

後処理

  1. additionwas introduced H2
  2. filtrationThe mixture was filtered through celite and
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-f941dcdf87b0401590f439875f967338
出典データセット
uspto-grants-2015_12
特許番号
US09206166B2

反応ノート

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