Tetrahydrofuran → 4-hydroxy-1-{4-[(2-tetrahydropyranyl)oxy]phenyl}-1H-pyridin-2-one

HRID 15042

反応式

HRID 15042 の反応式
C1COCC1.C([O:13][C:14]1[CH:19]=[CH:18][N:17]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH:27]3[CH2:32][CH2:31][CH2:30][CH2:29][O:28]3)=[CH:22][CH:21]=2)[C:16](=[O:33])[CH:15]=1)C1C=CC=CC=1>[Pd].CO>[OH:13][C:14]1[CH:19]=[CH:18][N:17]([C:20]2[CH:21]=[CH:22][C:23]([O:26][CH:27]3[CH2:32][CH2:31][CH2:30][CH2:29][O:28]3)=[CH:24][CH:25]=2)[C:16](=[O:33])[CH:15]=1

参加物

5

反応物 2

HCID 8028TetrahydrofuranHCID 684306714-benzyloxy-1-{4-[(2-tetrahydropyranyl)oxy]phenyl}-1H-pyridin-2-one

生成物 1

HCID 684287684-hydroxy-1-{4-[(2-tetrahydropyranyl)oxy]phenyl}-1H-pyridin-2-one

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Into a THF (25 mL)-MeOH (25 mL) mixed solvent solution of 4-benzyloxy-1-{4-[(2-tetrahydropyranyl)oxy]phenyl}-1H-pyridin-2-one (Step (1) of Example 12, 2.05 g, 5.4 mmols), 10% palladium-on-carbon (600 mg) was added. The atmosphere was hydrogen-substituted, and the reaction system was stirred at room temperature for 3.5 hours. The reaction liquid was filtered, the solvent was concentrated under reduced pressure, methanol was added to the resulting residue and the precipitate was recovered by filtration. Drying the same, the title compound (1.25 g, 80%) was obtained.

後処理

  1. additionwas added
  2. customThe reaction liquid
  3. filtrationwas filtered
  4. concentrationthe solvent was concentrated under reduced pressure, methanol
  5. additionwas added to the resulting residue
  6. filtrationthe precipitate was recovered by filtration
  7. dry with materialDrying the same, the title compound (1.25 g, 80%)
  8. customwas obtained

出典と根拠

ORDレコード
ord-4ed2fb8c276347ad8b5d9f43e33d617f
出典データセット
uspto-grants-2010_06
特許番号
US07732456B2

関連ノート

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