3-Methyl-1-benzofuran-5-ol → 3-Methyl-2,3-dihydrobenzofuran-5-ol

HRID 1504259ノート

反応式

HRID 1504259 の反応式
[CH3:1][C:2]1[C:6]2[CH:7]=[C:8]([OH:11])[CH:9]=[CH:10][C:5]=2[O:4][CH:3]=1>O1CCCC1.[Pd]>[CH3:1][CH:2]1[C:6]2[CH:7]=[C:8]([OH:11])[CH:9]=[CH:10][C:5]=2[O:4][CH2:3]1

参加物

4

反応物 1

HCID 135425263-Methyl-1-benzofuran-5-ol

生成物 1

HCID 678954423-Methyl-2,3-dihydrobenzofuran-5-ol収率 81.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

3-Methyl-benzofuran-5-ol (prepared as above in EXAMPLE III) (245 g, 1.6 mol) was added in tetrahydrofuran (THF) (450 mL) and hydrogenated with palladium on carbon (Pd/C) (5%, 2.4 g) under hydrogen (H2) (200 psi) at 145° C. for about 8 hours till gas chromatograph (GC) analysis showed completion of the reaction. The obtained mixture was filtered and distilled to afford 3-methyl-2,3-dihydro-benzofuran-5-ol (190 g, 1.3 mol).

後処理

  1. customcompletion of the reaction
  2. filtrationThe obtained mixture was filtered
  3. distillationdistilled

出典と根拠

ORDレコード
ord-c11bcba2ca1645d99619412d12e05742
出典データセット
uspto-grants-2015_12
特許番号
US09212336B2

反応ノート

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