4-tert-Butylcyclohexanone → 1-[4-(Tert-butyl)-1-cyclohexen-1-YL]pyrrolidine

HRID 1504993

反応式

HRID 1504993 の反応式
[C:1]([CH:5]1[CH2:10][CH2:9][C:8](=O)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[NH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1>C1(C)C=CC=CC=1>[C:1]([CH:5]1[CH2:10][CH2:9][C:8]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 73924-tert-ButylcyclohexanoneHCID 31268Pyrrolidine

生成物 1

HCID 1072321-[4-(Tert-butyl)-1-cyclohexen-1-YL]pyrrolidine

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A 50 mL round-bottomed flask containing 4-tert-butylcyclohexanone (6.01 gm) in anhydrous toluene (20 mL) was fitted with a Dean-Stark trap containing 3A molecular sieves, reflux condenser and a heating mantle. Pyrrolidine (6.00 mL) was added, and the solution heated to reflux for 18 hr. The solvent was evaporated and the crude product was used directly for the next reaction.

後処理

  1. customwas fitted with a Dean-Stark trap
  2. temperaturereflux condenser
  3. temperaturethe solution heated
  4. temperatureto reflux for 18 hr
  5. customThe solvent was evaporated
  6. customthe crude product was used directly for the next reaction

出典と根拠

ORDレコード
ord-bcf3b8f806d74b62bb2d057e7b5ce976
出典データセット
uspto-grants-2015_12
特許番号
US09216966B2

関連ノート

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