Hydrazine hydrate (1:1) → 4-(2,3-dimethylphenoxy)aniline

HRID 1505357ノート

反応式

HRID 1505357 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[C:12]=2[CH3:18])=[CH:6][CH:5]=1)([O-])=O.O.NN>C(O)C.[Pd]>[CH3:18][C:12]1[C:13]([CH3:17])=[CH:14][CH:15]=[CH:16][C:11]=1[O:10][C:7]1[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=1

参加物

5

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 6181291,2-Dimethyl-3-(4-nitrophenoxy)benzene2 回

生成物 1

HCID 71392004-(2,3-dimethylphenoxy)aniline収率 105%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

反応条件

温度
90 °C

実験手順

2,3-dimethylphenyl 4-nitrophenyl ether (Intermediate 73, 865 mg) was dissolved in ethanol (10 mL) to give a pale yellow solution. Hydrazine hydrate 50% (0.698 mL, 7.1 mmol) and Pd/C (37.8 mg, 0.36 mmol) were added. The reaction mixture was stirred at 90° C. for 1 hour. The reaction mixture was filtered and the organic phase was evaporated under vacuum to afford the title compound as a pale yellow oil (796 mg).

後処理

  1. customto give a pale yellow solution
  2. filtrationThe reaction mixture was filtered
  3. customthe organic phase was evaporated under vacuum

出典と根拠

ORDレコード
ord-a242059693db49dd9403348fc0f5d883
出典データセット
uspto-grants-2015_12
特許番号
US09216967B2

反応ノート

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