Water → Phenyl 1,3,4-thiadiazol-2-ylcarbamate
反応式
[S:1]1[CH:5]=[N:4][N:3]=[C:2]1[NH2:6].Cl[C:8]([O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:9].O>CC(N(C)C)=O>[S:1]1[CH:5]=[N:4][N:3]=[C:2]1[NH:6][C:8](=[O:9])[O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1参加物
5
実験手順
1,3,4-Thiadiazol-2-amine (253 mg, 2.50 mmol) in dimethylacetamide (3 mL) was stirred with phenyl chloroformate (392 μL, 3.13. mmol) at room temperature for one day. After addition of water, the precipitated solid was collected by filtration, washed with water and hexane and dried under reduced pressure to give the title compound as a colorless solid (418 mg, yield 76%).
後処理
- filtrationthe precipitated solid was collected by filtration
- washwashed with water and hexane
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-3f299e7c38fb4795818d3e990b21ae84
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09216999B2
反応ノート
読み込み中…