Ethyl bromoacetate → HCID 178472961、化合物
反応式
[NH:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[OH:12])=[N:2]1.C([O-])([O-])=O.[K+].[K+].Br[CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]>CC#N.O>[NH:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[O:12][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])=[N:2]1参加物
6
実験手順
To a solution of 2-(1H-pyrazol-3-yl) phenol (400 mg, 2.5 mmol) and K2CO3 (518 mg, 3.75 mmol) in CH3CN (10 mL) was added ethyl 2-bromoacetate (418 g, 2.5 mmol). The mixture was stirred at room temperature for 2 h, diluted with water, extracted with ethyl acetate and concentrated. The crude material was purified by column chromatography. (129 mg, yield 21%) MS (ESI+) e/z: 247.2 [M+1]+.
後処理
- extractionextracted with ethyl acetate
- concentrationconcentrated
- customThe crude material was purified by column chromatography
出典と根拠
- ORDレコード
- ord-724bc99a721e4a4dad4dd93933c94839
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09221794B2
反応ノート
読み込み中…