Ethyl bromoacetate → Ethyl 2-(2-(methylsulfonyl)phenoxy)acetate

HRID 1507033ノート

反応式

HRID 1507033 の反応式
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[OH:11])(=[O:4])=[O:3].C([O-])([O-])=O.[K+].[K+].Br[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>CC#N.O>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])(=[O:3])=[O:4]

参加物

6

反応物 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 5989982-Methanesulfonylphenol

生成物 1

HCID 86729449Ethyl 2-(2-(methylsulfonyl)phenoxy)acetate収率 94%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6342Acetonitrile溶媒

反応条件

温度
80 °C

実験手順

To a solution of 2-(methylsulfonyl)phenol (100 mg, 0.58 mmol) and K2CO3 (276 mg, 2 mmol) in CH3CN (10 mL) was added ethyl 2-bromoacetate (115.2 mg, 0.69 mmol) at 25° C. The mixture was heated at 80° C. for 4 h, diluted with water and extracted with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate and concentrated. The crude product was used in the next step without further purification. (140 mg, yield 94%).

後処理

  1. extractionextracted with ethyl acetate
  2. washThe combined organic layers were washed with brine
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated
  5. customThe crude product was used in the next step without further purification

出典と根拠

ORDレコード
ord-8f4369eea7ee4feda7a9a58b0b1562f3
出典データセット
uspto-grants-2015_12
特許番号
US09221794B2

反応ノート

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