Hydrazinecarboxylic acid, ethyl ester → HCID 178473565、化合物

HRID 1509136ノート

反応式

HRID 1509136 の反応式
[C:1]([O:5][C:6](=[O:35])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:19]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[CH:20][C:21]4[NH:26][C:25](=S)[CH2:24][O:23][C:22]=4[N:28]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[NH:36]([C:38]([O:40][CH2:41][CH3:42])=[O:39])[NH2:37]>C1COCC1>[C:1]([O:5][C:6]([NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:19]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[CH:20][C:21]4[NH:26][C:25](=[N:37][NH:36][C:38]([O:40][CH2:41][CH3:42])=[O:39])[CH2:24][O:23][C:22]=4[N:28]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)=[O:35])([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 20064Hydrazinecarboxylic acid, ethyl esterHCID 86683631Tert-butyl (1-(4-(7-phenyl-2-thioxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

生成物 1

HCID 178473565HCID 178473565、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of tert-butyl(1-(4-(7-phenyl-2-thioxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate (20 mg, 0.04 mmol) in dry THF (1 mL) was added ethyl hydrazinecarboxylate (21 mg, 0.20 mmol) and mercuric acetate (21 mg, 0.06 mmol) under nitrogen. The reaction mixture was stirred for 2 h at room temperature, filtered on celite and concentrated to dryness under reduced pressure to give the title compound which was used without purification in the next step.

後処理

  1. filtrationfiltered on celite and
  2. concentrationconcentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-3ccca1324a7d4efcbbd04b79ebb13e54
出典データセット
uspto-grants-2015_12
特許番号
US09221838B2

反応ノート

読み込み中…