Water → Salvinorin B

HRID 1509364

反応式

HRID 1509364 の反応式
CC([O:4][C@@H:5]1[C:19](=[O:20])[C@H:18]2[C@@:8]([CH3:27])([CH2:9][CH2:10][C@@H:11]3[C@:17]2([CH3:21])[CH2:16][C@@H:15]([C:22]2[CH:23]=[CH:24][O:25][CH:26]=2)[O:14][C:12]3=[O:13])[C@H:7]([C:28]([O:30][CH3:31])=[O:29])[CH2:6]1)=O.C(=O)([O-])[O-].[Na+].[Na+].O>CO>[CH3:27][C@:8]12[C@H:7]([C:28]([O:30][CH3:31])=[O:29])[CH2:6][C@H:5]([OH:4])[C:19](=[O:20])[C@@H:18]1[C@:17]1([CH3:21])[C@H:11]([C:12]([O:14][C@H:15]([C:22]3[CH:23]=[CH:24][O:25][CH:26]=3)[CH2:16]1)=[O:13])[CH2:10][CH2:9]2

参加物

5

反応物 3

HCID 962WaterHCID 10340Sodium CarbonateHCID 128563Salvinorin A

生成物 1

HCID 11440685Salvinorin B収率 42.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of Salvinorin A (500 mg, 1.15 mM) in methanol (10 ml) was added solid sodium carbonate (490 mg, 4.6 mM) and the mixture stirred at room temperature overnight. Water (20 ml) was added to mixture and the mixture stirred for 30 mins. The solution was filtered and the filter-cake washed with ice-cold water (20 ml) and ice-cold methanol (20 ml) and dried in a dessicator to give Salvinorin B (191 mg, 42%).

後処理

  1. stirringthe mixture stirred for 30 mins
  2. filtrationThe solution was filtered
  3. washthe filter-cake washed with ice-cold water (20 ml) and ice-cold methanol (20 ml)
  4. customdried in a dessicator

出典と根拠

ORDレコード
ord-fde16edeb1b248fdb5fe3b8ab8ff05a5
出典データセット
uspto-grants-2015_12
特許番号
US09222949B2

関連ノート

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