Hydrochloric Acid → Ceftiofur Hydrochloride

HRID 1510807ノート

反応式

HRID 1510807 の反応式
[CH3:1][O:2]/[N:3]=[C:4](\[C:11]([NH:13][C@@H:14]1[C:17](=[O:18])[N:16]2[C:19]([C:32]([O-:34])=[O:33])=[C:20]([CH2:23][S:24][C:25]([C:27]3[O:31][CH:30]=[CH:29][CH:28]=3)=[O:26])[CH2:21][S:22][C@H:15]12)=[O:12])/[C:5]1[N:9]=[C:8]([NH2:10])[S:7][CH:6]=1.[Na+].[Cl-:36].[Na+].Cl.C(OC(C)C)(C)C>O.C1COCC1>[CH3:1][O:2]/[N:3]=[C:4](\[C:11]([NH:13][C@@H:14]1[C:17](=[O:18])[N:16]2[C:19]([C:32]([OH:34])=[O:33])=[C:20]([CH2:23][S:24][C:25]([C:27]3[O:31][CH:30]=[CH:29][CH:28]=3)=[O:26])[CH2:21][S:22][C@H:15]12)=[O:12])/[C:5]1[N:9]=[C:8]([NH2:10])[S:7][CH:6]=1.[ClH:36]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 7914Diisopropyl EtherHCID 23671563Ceftiofur Sodium

生成物 1

HCID 9937686Ceftiofur Hydrochloride

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a suspension of crystalline Ceftiofur sodium (10 g) in water (30 ml) was added THF (87 ml) at 10-30° C. To that sodium chloride (14 g) was added. pH of the solution was adjusted to 2.5-3.5. Organic layer pH was adjusted to 0.5-1.5 using conc. HCl. Addition of diisopropyl ether followed by filtration yielded pure title compound.]

後処理

  1. filtrationfollowed by filtration

出典と根拠

ORDレコード
ord-d0d23c507255493f9027168858d1b6d2
出典データセット
uspto-grants-2012_07
特許番号
US08212024B2

反応ノート

読み込み中…