Hydrochloric Acid → 2,6-Dibromo-3-pyridinecarboxylic acid

HRID 1512976ノート

反応式

HRID 1512976 の反応式
[Br:1][C:2]1[C:7]([CH:8]=[O:9])=[CH:6][CH:5]=[C:4]([Br:10])[N:3]=1.P([O-])(O)(O)=[O:12].[Na+].CC(=CC)C.Cl([O-])=O.[Na+].Cl>C(O)(C)(C)C.O>[Br:1][C:2]1[N:3]=[C:4]([Br:10])[CH:5]=[CH:6][C:7]=1[C:8]([OH:12])=[O:9]

参加物

8

反応物 5

HCID 313Hydrochloric AcidHCID 105532-Methyl-2-buteneHCID 122593842,6-Dibromopyridine-3-carbaldehydeHCID 23668197Sodium ChloriteHCID 23672064Monosodium phosphate

生成物 1

HCID 122593872,6-Dibromo-3-pyridinecarboxylic acid収率 88%

試薬・触媒・溶媒 2

HCID 962Water溶媒3 回HCID 6386tert-Butanol溶媒

実験手順

To a solution of 2,6-dibromo-3-formylpyridine (0.3 g) in tert-butanol (12 mL)-water (1 mL) were added sodium dihydrogen phosphate (0.14 g), 2-methyl-2-butene (0.32 g) and a solution of sodium chlorite (0.36 g) in water (2 mL) successively at room temperature, and the mixture was stirred for 2 hours. The reaction mixture was poured into water. The mixture was acidified by adding 1 mol/L hydrochloric acid, and the resulting mixture was extracted with ethyl acetate. The extract was washed with water, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (0.28 g).

後処理

  1. extractionthe resulting mixture was extracted with ethyl acetate
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-bb873ee1f03747e2a1067c41fa17e7bf
出典データセット
uspto-grants-2012_07
特許番号
US08217069B2

反応ノート

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