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Hydrochloric Acid → 3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-indol-2-yl]-3,5-dimethylphenyl}-propionic acid

HRID 1514960
ノート
印刷プレビュー

反応式

HRID 1514960 の反応式
C[O:2][C:3](=[O:36])[CH2:4][CH2:5][C:6]1[CH:11]=[C:10]([CH3:12])[C:9]([C:13]2[NH:14][C:15]3[C:20]([CH:21]=2)=[CH:19][CH:18]=[C:17]([C:22](=[O:34])[NH:23][C:24]2[CH:29]=[CH:28][C:27]([C:30]([CH3:33])([CH3:32])[CH3:31])=[CH:26][CH:25]=2)[CH:16]=3)=[C:8]([CH3:35])[CH:7]=1.[OH-].[Na+].Cl>C1COCC1.CCOCC>[C:30]([C:27]1[CH:28]=[CH:29][C:24]([NH:23][C:22]([C:17]2[CH:16]=[C:15]3[C:20]([CH:21]=[C:13]([C:9]4[C:8]([CH3:35])=[CH:7][C:6]([CH2:5][CH2:4][C:3]([OH:36])=[O:2])=[CH:11][C:10]=4[CH3:12])[NH:14]3)=[CH:19][CH:18]=2)=[O:34])=[CH:25][CH:26]=1)([CH3:33])([CH3:32])[CH3:31]
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 669660003-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-indol-2-yl]-3,5-dimethylphenyl}-propionic acid methyl ester

生成物 1

HCID 669651463-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-indol-2-yl]-3,5-dimethylphenyl}-propionic acid

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒
HCID 8028
Tetrahydrofuran
溶媒

反応条件

温度
50 °C

実験手順

A mixture of 3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-indol-2-yl]-3,5-dimethylphenyl}-propionic acid methyl ester and 1N NaOH (500 μL) in THF (5 mL) was heated at 50° C. for 18 h. The mixture was cooled and was neutralized with one equivalent of 1N HCl and partitioned between water and ethyl acetate. The ethyl acetate layer was dried, filtered, and the solvent removed under reduced pressure to leave an oil, which was twice taken up in ether and solvent removed under reduced pressure to give 3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-indol-2-yl]-3,5-dimethylphenyl}-propionic acid. 1H NMR (Acetonitrile-d3, 400 MHz): δ 9.62 (s, 1H), 8.72 (s, 1H), 8.04 (s, 1H), 7.63 (m, 4H), 7.40 (d, J=8.7 Hz, 2H), 7.03 (s, 2H), 6.40 (s, 1H), 2.87 (t, J=7.6 Hz, 2H), 2.63 (t, J=7.7 Hz, 2H), 2.11 (s, 6H), 1.32 (s, 9H). MS (m/z) 469.3 (M+1); Retention time=1.50 min (Method 10).

後処理

  1. temperatureThe mixture was cooled
  2. custompartitioned between water and ethyl acetate
  3. dry with materialThe ethyl acetate layer was dried
  4. filtrationfiltered
  5. customthe solvent removed under reduced pressure
  6. customto leave an oil, which
  7. customsolvent removed under reduced pressure

出典と根拠

ORDレコード
ord-dd56a719c06d43be86fe6c24b8bed073
出典データセット
uspto-grants-2012_07
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08222248B2

反応ノート

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このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート