4-Chlorophenyl Isocyanate → HCID 59569062、化合物

反応式

[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[N:10]=[C:9]([C:11]2[CH:25]=[CH:24][C:14]3[N:15]([CH3:23])[C:16]([C:18]4[O:19][CH:20]=[CH:21][CH:22]=4)=[N:17][C:13]=3[CH:12]=2)[CH2:8][S:7][C:6]1=[O:26].[Cl:27][C:28]1[CH:33]=[CH:32][C:31]([N:34]=[C:35]=[O:36])=[CH:30][CH:29]=1.C1COCC1>C(N(CC)CC)C>[Cl:27][C:28]1[CH:33]=[CH:32][C:31]([NH:34][C:35]([NH:1][CH2:2][CH2:3][CH2:4][N:5]2[N:10]=[C:9]([C:11]3[CH:25]=[CH:24][C:14]4[N:15]([CH3:23])[C:16]([C:18]5[O:19][CH:20]=[CH:21][CH:22]=5)=[N:17][C:13]=4[CH:12]=3)[CH2:8][S:7][C:6]2=[O:26])=[O:36])=[CH:30][CH:29]=1

参加物

実験手順

120 mg (0.30 mM) of 3-(3-aminopropyl)-5-[2-(2-furyl)-1-methyl-1H-benzimidazol-5-yl]-3,6-dihydro-2H-1,3,4-thiadiazin-2-one and 50.1 mg (0.33 mM) of 1-chloro-4-isocyanatobenzene are added to 2 ml of THF and 164.33 μl (1.33 mM) of triethylamine. The mixture is stirred at room temperature for 20 hours. The solid is filtered off and washed with water and then with isopropanol to give, after drying, 106 mg of N-(4-chlorophenyl)-N′-{3-[5-[2-(2-furyl)-1-methyl-1H-benzimidazol-5-yl]-2-oxo-2H-1,3,4-thiadiazin-3(6H)-yl]propyl}urea.