Tetrahydrofuran → HCID 178491755、化合物
反応式
S(Cl)([Cl:3])=O.O[CH2:6][C:7]1[C:12]2[NH:13][C:14]([CH2:16][N:17]([CH3:31])[S:18]([C:21]3[C:26]([CH3:27])=[CH:25][C:24]([O:28][CH3:29])=[CH:23][C:22]=3[CH3:30])(=[O:20])=[O:19])=[N:15][C:11]=2[CH:10]=[CH:9][CH:8]=1.C1COCC1>C(OCC)(=O)C>[Cl:3][CH2:6][C:7]1[C:12]2[NH:13][C:14]([CH2:16][N:17]([CH3:31])[S:18]([C:21]3[C:26]([CH3:27])=[CH:25][C:24]([O:28][CH3:29])=[CH:23][C:22]=3[CH3:30])(=[O:20])=[O:19])=[N:15][C:11]=2[CH:10]=[CH:9][CH:8]=1参加物
5
実験手順
Thionyl chloride (3.22 mmol, 2.5 eq.) was added to a cooled (0° C.) solution of N-((7-(hydroxymethyl)-1H-benzo[d]imidazol-2-yl)methyl)-4-methoxy-N,2,6-trimethylbenzenesulfonamide (1.29 mmol, 1.0 eq.) in abs. THF (10 ml). The reaction mixture was stirred at room temperature for 24 h. The mixture was then diluted with ethyl acetate and washed successively with NaHCO3 solution and NaCl solution. The organic phase was dried over Na2SO4 and the solvent was distilled off in vacuo to obtain the crude product, which led to the desired product by purification by column chromatography over silica gel. Yield: 76%