Acetaldehyde → 2-Ethylcyclohexane-1,3-dione

HRID 1519401ノート

反応式

HRID 1519401 の反応式
[C:1]1(=[O:8])[CH2:6][CH2:5][CH2:4][C:3](=[O:7])[CH2:2]1.[CH3:9][CH:10]=O.CCOC(C1CC(C(OCC)=O)=C(C)NC=1C)=O.N1C=CC=CC=1>CO.C(Cl)Cl>[CH2:9]([CH:2]1[C:3](=[O:7])[CH2:4][CH2:5][CH2:6][C:1]1=[O:8])[CH3:10]

参加物

7

反応物 4

HCID 177AcetaldehydeHCID 1049PyridineHCID 104341,3-CyclohexanedioneHCID 70849Hantzsch ester

生成物 1

HCID 108988052-Ethylcyclohexane-1,3-dione収率 69%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6344Dichloromethane溶媒

実験手順

1,3-Cyclohexanedione (10 g, 89.2 mmol), 40% aqueous CH3CHO (49.4 g, 445.9 mmol) were dissolved in methanol (40 mL) followed by addition of Hantzsch ester (22.7 g, 89.2 mmol) and pyridine (2.1 g, 18.74 mmol) under nitrogen. The resulting light yellow mixture was stirred at room temperature overnight, then concentrated to give crude product that was re-slurried in a mixture of CH2Cl2 (40 mL) and hexanes (60 mL) to furnish 2-ethyl-1,3-cyclohexanedione (8.6 g, 69%).

後処理

  1. concentrationconcentrated
  2. customto give crude product that

出典と根拠

ORDレコード
ord-0be1b85333fe4f2e857f2598abcd2658
出典データセット
uspto-grants-2015_07
特許番号
US09073888B2

反応ノート

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