Pyridine → HCID 86694483、化合物
反応式
[CH2:1]([C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[C:6]([O:12][CH:13]([F:15])[F:14])[CH:5]=1)[CH:2]=C.N1C=CC=CC=1.[O:22]=[O+][O-]>C(Cl)Cl.CO>[F:14][CH:13]([F:15])[O:12][C:6]1[CH:5]=[C:4]([CH2:1][CH:2]=[O:22])[CH:11]=[CH:10][C:7]=1[C:8]#[N:9]参加物
5
反応条件
- 温度
- -78 °C
実験手順
A solution of 4-allyl-2-(difluoromethoxy)benzonitrile (600 mg, 2.9 mmol) in 1:1 CH2Cl2/MeOH (15 mL) containing pyridine (0.5 mL, 6 mmol) was cooled to −78° C., and O3 was passed through until a blue color was present. N2 was then bubbled through to discharge the blue color and Me2S (5 ml) was added. The reaction mixture was allowed to warm and left overnight. The mixture was washed with 1 N HCl, aqueous NaHCO3, dried and concentrated to give crude 2-(difluoromethoxy)-4-(2-oxoethyl)benzonitrile.
後処理
- customN2 was then bubbled through
- additionwas added
- temperatureto warm
- washThe mixture was washed with 1 N HCl, aqueous NaHCO3
- customdried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-6b9fb73dc52842eeaac7b46cdc55eff2
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09073882B2
反応ノート
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