N-bromobutanimide → 1239464-76-6
反応式
[S:1]1[C:5]([NH:6][C:7](=[O:13])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:4][N:3]=[CH:2]1.[Br:14]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[Br:14][C:4]1[N:3]=[CH:2][S:1][C:5]=1[NH:6][C:7](=[O:13])[O:8][C:9]([CH3:10])([CH3:12])[CH3:11]参加物
4
実験手順
To a solution of tert-butyl thiazol-5-ylcarbamate (WO 2007/071955) (607 mg, 3.0 mmol) in chloroform (50 mL) was added N-bromosuccinimide (542 mg, 3.04 mmol) at 0° C. After 1 h, reaction was quenched by addition of saturated NaHCO3 solution (50 mL). The layers were separated, and the mixture extracted with CHCl3 (3×50 mL). The combined organic extracts were dried (MgSO4), filtered and concentrated. 1H NMR (CDCl3) δ8.37 (d, J=0.6 Hz, 1H), 7.05 (br s, 1H), 1.55 (s, 9H); MH+ 278.9.
後処理
- customreaction
- customwas quenched by addition of saturated NaHCO3 solution (50 mL)
- customThe layers were separated
- extractionthe mixture extracted with CHCl3 (3×50 mL)
- dry with materialThe combined organic extracts were dried (MgSO4)
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-20c725f09efa4c998da4da93414d47e3
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09073891B2
反応ノート
読み込み中…