Ammonium formate → HCID 63758165、化合物
反応式
C([O-])=O.[NH4+].Cl[C:6]1[N:11]=[C:10]2[N:12]([CH2:16][CH3:17])[C:13]([NH2:15])=[N:14][C:9]2=[CH:8][CH:7]=1>C(O)C.[Pd]>[CH2:16]([N:12]1[C:10]2=[N:11][CH:6]=[CH:7][CH:8]=[C:9]2[N:14]=[C:13]1[NH2:15])[CH3:17]参加物
5
実験手順
Ammonium formate (1.55 g, 24.6 mmol) is added to a solution of 5-chloro-3-ethyl-3H-imidazo[4,5-b]pyridin-2-amine (410 mg, 2.09 mmol) in ethanol (10 mL) containing 10% palladium on carbon (40 mg). The mixture is stirred at room temperature for 16 h. The reaction is filtered, concentrated under reduced pressure and the residue is purified via flash column chromatography using a gradient elution of 0-10% CH2Cl2/methanol to afford the title compound (192 mg, 57%).
後処理
- filtrationThe reaction is filtered
- concentrationconcentrated under reduced pressure
- customthe residue is purified via flash column chromatography
- washa gradient elution of 0-10% CH2Cl2/methanol
出典と根拠
- ORDレコード
- ord-69565b8695ff41d99d7d4a83e4316466
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09073926B2
反応ノート
読み込み中…