2,2,2-Trifluoroethanol → 6-(2,2,2-Trifluoroethoxy)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine

反応式

[F:1][C:2]([F:6])([F:5])[CH2:3][OH:4].[H-].[Na+].Br.Cl[C:11]1[CH:12]=[CH:13][C:14]2[N:15]([C:17]([NH2:20])=[N:18][N:19]=2)[N:16]=1>>[F:1][C:2]([F:6])([F:5])[CH2:3][O:4][C:11]1[CH:12]=[CH:13][C:14]2[N:15]([C:17]([NH2:20])=[N:18][N:19]=2)[N:16]=1

参加物

反応物 3

HCID 64092,2,2-Trifluoroethanol

HCID 24758Sodium hydride

HCID 866507946-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine hydrobromide

生成物 1

HCID 581368996-(2,2,2-Trifluoroethoxy)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine

実験手順

2,2,2-Trifluoroethanol (1 ml), sodium hydride (86 mg) and 6-chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine hydrobromide (W2.001, 100 mg) were reacted according to W1.004. 87 mg of the title compound were obtained in solid form.

出典と根拠

ORDレコード: ord-543d0739916943fba51d47594af46ddf
出典データセット: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09079906B2

反応ノート

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