Benzyl 4-(benzyloxy)-2-(1H-pyrazol-1-yl)pyrimidin-5-ylcarbamate → HCID 178508031、化合物
反応式
C([O:8][C:9]1[C:14]([NH:15]C(=O)OCC2C=CC=CC=2)=[CH:13][N:12]=[C:11]([N:26]2[CH:30]=[CH:29][CH:28]=[N:27]2)[N:10]=1)C1C=CC=CC=1.[H][H]>C1COCC1.[Pd]>[NH2:15][C:14]1[C:9]([OH:8])=[N:10][C:11]([N:26]2[CH:30]=[CH:29][CH:28]=[N:27]2)=[N:12][CH:13]=1参加物
5
実験手順
Benzyl 4-(benzyloxy)-2-(1H-pyrazol-1-yl)pyrimidin-5-ylcarbamate, 11-d, (1.96 g, 4.9 mmol) was hydrogenated with hydrogen ballon in THF (20 ml) and Pd/C (200 mg) at room temperature for 12 hours. The mixture was filtered through a celite pad and the filtrate was concentrated under vacuum to provide the product, 11-e, (0.8 g, 93%). 1H NMR (DMSO-d6, 300 MHz,): δ 8.39 (s, 1H), 7.80 (s, 1H), 7.20 (s, 1H), 6.56 (m, 1H), 5.00 (br, 2H).
後処理
- filtrationThe mixture was filtered through a celite pad
- concentrationthe filtrate was concentrated under vacuum
出典と根拠
- ORDレコード
- ord-76848d5fd28c47a391195e376273e6e2
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09079930B2
反応ノート
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