2-Methoxyethylamine → HCID 89510331、化合物

HRID 1525367ノート

反応式

HRID 1525367 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:45]2[CH:49]=[N:48][N:47]=[N:46]2)=[C:6](/[CH:8]=[CH:9]/[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][C:18]=3[C:22](=[O:28])[NH:23][CH2:24][CH2:25][O:26][CH3:27])[CH:13]2[C:29]([NH:31][C:32]2[CH:44]=[CH:43][C:35]([C:36]([O:38]C(C)(C)C)=[O:37])=[CH:34][CH:33]=2)=[O:30])=[O:11])[CH:7]=1.COCCN.F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1.CCN(C(C)C)C(C)C>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:45]2[CH:49]=[N:48][N:47]=[N:46]2)=[C:6](/[CH:8]=[CH:9]/[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][C:18]=3[C:22](=[O:28])[NH:23][CH2:24][CH2:25][O:26][CH3:27])[CH:13]2[C:29]([NH:31][C:32]2[CH:33]=[CH:34][C:35]([C:36]([OH:38])=[O:37])=[CH:43][CH:44]=2)=[O:30])=[O:11])[CH:7]=1

参加物

6

反応物 4

HCID 80182-MethoxyethylamineHCID 81531DiisopropylethylamineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 131733150HCID 131733150、化合物

生成物 1

HCID 89510331HCID 89510331、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

(E)-tert-Butyl 4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(2-methoxyethylcarbamoyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate: To 3A (46 mg, 0.073 mmol), 2-methoxyethanamine (5.49 mg, 0.073 mmol), BOP (32.3 mg, 0.073 mmol) in DMF (1 mL) was added DIEA (12.77 μL, 0.073 mmol). After 24 h, the reaction was quenched with H2O (10 mL) and extracted with EtOAc (3×20 mL). The combined organic layers were washed with brine (10 mL) and dried (MgSO4). MS (ESI) m/z: 686.0 (M+H)+.

後処理

  1. customthe reaction was quenched with H2O (10 mL)
  2. extractionextracted with EtOAc (3×20 mL)
  3. washThe combined organic layers were washed with brine (10 mL)
  4. dry with materialdried (MgSO4)

出典と根拠

ORDレコード
ord-0d107f98066d4dc0b52fb5381e438896
出典データセット
uspto-grants-2015_07
特許番号
US09079929B2

反応ノート

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