Diisopropyl Ether → tert-butyl (R)-3-((5-carbamoyl-3-ethyl-6-((4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrazin-2-yl)oxy)pyrrolidine-1-carboxylate

反応式

[C:1]([C:4]1[N:5]=[C:6]([CH2:24][CH3:25])[C:7]([O:11][C@@H:12]2[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13]2)=[N:8][C:9]=1Cl)(=[O:3])[NH2:2].[CH3:26][N:27]1[CH2:32][CH2:31][N:30]([CH:33]2[CH2:38][CH2:37][N:36]([C:39]3[CH:45]=[CH:44][C:42]([NH2:43])=[CH:41][CH:40]=3)[CH2:35][CH2:34]2)[CH2:29][CH2:28]1.C(N(C(C)C)CC)(C)C.C(OC(C)C)(C)C>O.CN1CCCC1=O>[C:1]([C:4]1[N:5]=[C:6]([CH2:24][CH3:25])[C:7]([O:11][C@@H:12]2[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13]2)=[N:8][C:9]=1[NH:43][C:42]1[CH:44]=[CH:45][C:39]([N:36]2[CH2:37][CH2:38][CH:33]([N:30]3[CH2:31][CH2:32][N:27]([CH3:26])[CH2:28][CH2:29]3)[CH2:34][CH2:35]2)=[CH:40][CH:41]=1)(=[O:3])[NH2:2]