ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Ethylenediamine → (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid ethylenediamine salt hydrate

HRID 1526423
ノート
印刷プレビュー

反応式

HRID 1526423 の反応式
[Cl:1][C:2]1[C:10]2[CH:9]=[C:8]([O:11][CH2:12][C:13]3[CH:18]=[CH:17][C:16]([O:19][CH:20]([CH3:22])[CH3:21])=[C:15]([C:23]([F:26])([F:25])[F:24])[CH:14]=3)[CH:7]=[CH:6][C:5]=2[N:4]2[CH2:27][CH2:28][C@H:29]([CH2:30][C:31]([OH:33])=[O:32])[C:3]=12.[CH2:34]([NH2:37])[CH2:35][NH2:36].C(#N)C>C1COCC1>[OH2:11].[CH2:34]([NH2:37])[CH2:35][NH2:36].[Cl:1][C:2]1[C:10]2[CH:9]=[C:8]([O:11][CH2:12][C:13]3[CH:18]=[CH:17][C:16]([O:19][CH:20]([CH3:22])[CH3:21])=[C:15]([C:23]([F:24])([F:25])[F:26])[CH:14]=3)[CH:7]=[CH:6][C:5]=2[N:4]2[CH2:27][CH2:28][C@H:29]([CH2:30][C:31]([OH:33])=[O:32])[C:3]=12
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 3301EthylenediamineHCID 6342AcetonitrileHCID 53362086(R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

生成物 1

HCID 131733173(R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid ethylenediamine salt hydrate

試薬・触媒・溶媒 1

HCID 8028
Tetrahydrofuran
溶媒

実験手順

(R)-2-(9-Chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid (15 mg) was dissolved in THF (0.5 mL) and aqueous ethylenediamine (16 uL, 2.27 M) was added. The homogeneous solution was left to stir at room temperature for 2d. ACN (300 μL) was then added and the reaction was stirred at room temperature for one additional day. The reaction mixture was evaporated to dryness and 0.5 mL of EtOAc was added. After stiffing for 24 h at room temperature, a solid had formed which was collected by filtration. The PXRD pattern of the title compound is shown in FIG. 10; and the DSC and TGA are shown in FIG. 11.

後処理

  1. waitThe homogeneous solution was left
  2. customThe reaction mixture was evaporated to dryness and 0.5 mL of EtOAc
  3. additionwas added
  4. customa solid had formed which
  5. filtrationwas collected by filtration

出典と根拠

ORDレコード
ord-573e21a452624ed8acf5f1575512fa33
出典データセット
uspto-grants-2015_07
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09085581B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート