Sodium Hydroxide → 6-[(E)-N-hydroxy-C-[(2R)-2-(2-methylphenyl)-2-(4-methylsulfonylphenyl)ethyl]carbonimidoyl]-2-methylpyridazin-3-one

反応式

[NH:1]1CCC[C@H]1C(O)=O.[OH-:9].[Na+].Br[C:12]1[CH:17]=[CH:16][C:15]([C@H:18]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=2[CH3:39])[CH2:19][C:20]2([C:25]3[CH:26]=[CH:27][C:28](=[O:32])[N:29]([CH3:31])[N:30]=3)OCCO2)=[CH:14][CH:13]=1.[CH3:40][S:41]([O-:43])=[O:42].[Na+]>[Cu]I.CS(C)=O>[OH:9]/[N:1]=[C:20](/[C:25]1[CH:26]=[CH:27][C:28](=[O:32])[N:29]([CH3:31])[N:30]=1)\[CH2:19][C@H:18]([C:15]1[CH:16]=[CH:17][C:12]([S:41]([CH3:40])(=[O:43])=[O:42])=[CH:13][CH:14]=1)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[CH3:39]