Tetrafluoro-m-phenylenediamine dihydrochloride → Racemic 3-chloro-4-[(4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one dihydrochloride

HRID 15304

反応式

HRID 15304 の反応式
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[CH:6]=[CH:7][C:8](=[O:34])[N:9]3[CH2:13][CH:12]([CH2:14][N:15]4[CH2:20][CH2:19][CH:18]([NH:21][CH2:22][C:23]5[CH:24]=[CH:25][C:26]6[S:27][CH2:28][C:29](=[O:33])[NH:30][C:31]=6[N:32]=5)[CH2:17][CH2:16]4)[C:11]=1[C:10]=23.C1(N)C(F)=C(F)C(F)=C(N)C=1F.[ClH:47].Cl.Cl.C(OCC)C>C(Cl)(Cl)Cl>[ClH:1].[ClH:47].[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[CH:6]=[CH:7][C:8](=[O:34])[N:9]3[CH2:13][CH:12]([CH2:14][N:15]4[CH2:20][CH2:19][CH:18]([NH:21][CH2:22][C:23]5[CH:24]=[CH:25][C:26]6[S:27][CH2:28][C:29](=[O:33])[NH:30][C:31]=6[N:32]=5)[CH2:17][CH2:16]4)[C:11]=1[C:10]=23

参加物

5

反応物 3

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 10953452Ether hydrochlorideHCID 24871549Racemic 3-chloro-4-[(4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one

生成物 1

HCID 68685184Racemic 3-chloro-4-[(4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one dihydrochloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Racemic 3-chloro-4-[(4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one was converted to the dihydrochloride by dissolving in chloroform and adding 1M HCl/diethyl ether then evaporating to dryness. MS as that of free base.

後処理

  1. customthen evaporating to dryness

出典と根拠

ORDレコード
ord-5c06d8d3ee3c47bbbd4173856818d6b2
出典データセット
uspto-grants-2010_06
特許番号
US07732461B2

関連ノート

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