Toluene → HCID 3635836、化合物

HRID 1532651ノート

反応式

HRID 1532651 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1.Cl[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[N+:18]([O-:20])=[O:19].C1(C)C=CC=CC=1>N1C=CC=CC=1>[O:8]1[CH2:9][CH2:10][N:5]([CH2:4][CH2:3][CH2:2][NH:1][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N+:18]([O-:20])=[O:19])[CH2:6][CH2:7]1

参加物

5

反応物 3

HCID 1140TolueneHCID 69451-Chloro-2-nitrobenzeneHCID 61055N-(3-Aminopropyl)morpholine

生成物 1

HCID 3635836HCID 3635836、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
130 °C

実験手順

N-(3-Aminopropyl)morpholine (1.04 ml) was added to a solution containing 2-chloronitrobenzene (1.005 g) in pyridine (0.78 ml), and stirred for 14 hours at 130° C. Toluene was added to the reaction mixture and concentrated. The residue, with ethyl acetate added thereto, was extracted with 1N hydrochloric acid aqueous solution. The extract was alkalified with 1N sodium hydroxide aqueous solution and extracted with ethyl acetate. The extract was washed with saturated brine, dried over sodium sulfate anhydride, and concentrated, thereby yielding the entitled compound (1.217 g) as orange oil.

後処理

  1. concentrationconcentrated
  2. additionThe residue, with ethyl acetate added
  3. extractionwas extracted with 1N hydrochloric acid aqueous solution
  4. extractionextracted with ethyl acetate
  5. washThe extract was washed with saturated brine
  6. dry with materialdried over sodium sulfate anhydride
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-f1b70ab4fa164e28be5f6a784ebfd0fa
出典データセット
uspto-grants-2001_03
特許番号
US06204264B1

反応ノート

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