Sodium Hydroxide → HCID 22013885、化合物

反応式

[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]1[O:11][C:12]([CH3:30])=[C:13]([CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][C:26]([O:28]C)=[O:27])=[CH:20][CH:19]=2)[N:14]=1.[OH-].[Na+]>CO.O1CCCC1>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]1[O:11][C:12]([CH3:30])=[C:13]([CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][C:26]([OH:28])=[O:27])=[CH:20][CH:19]=2)[N:14]=1

参加物

実験手順

Methyl 3-[4-[2-(2-(benzothiophen-2-yl)-5-methyl-4-oxazolyl)ethoxy]phenyl]propionate (1.90 g, 4.51 mmol) obtained in Example 13 was dissolved in methanol (20 ml) and tetrahydrofuran (30 ml), and 2.5N aqueous sodium hydroxide solution (2.2 ml, 5.5 mmol) was added at room temperature, which was followed by stirring for 13 hr. Then, the solvent was evaporated and water was added to the obtained residue. 1N Hydrochloric acid was added to acidify the solution and the precipitated white solid was collected by filtration, washed with water and dried to give the title compound (1.80 g, yield 98%) as a white solid.