Methanol → Quizalofop

HRID 1534310

反応式

HRID 1534310 の反応式
CO.[Cl:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([O:14][C:15]1[CH:27]=[CH:26][C:18]([O:19][CH:20]([CH3:25])[C:21]([O:23]C)=[O:22])=[CH:17][CH:16]=1)[CH:8]=[N:7]2.[OH-].[Na+]>O1CCCC1>[Cl:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([O:14][C:15]1[CH:16]=[CH:17][C:18]([O:19][CH:20]([CH3:25])[C:21]([OH:23])=[O:22])=[CH:26][CH:27]=1)[CH:8]=[N:7]2

参加物

5

反応物 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 187101Quizalofop-methyl

生成物 1

HCID 178795Quizalofop収率 76.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Into a mixture of methanol (10 ml) and tetrahydrofuran (14 ml), methyl 2-[4-(6-chloro-2-quinoxalinyloxy)phenoxy]propionate (0.6 g) was dissolved, and lN sodium hydroxide solution (2.5 ml) was added thereto. The reaction was carried out at room temperature while stirring for 2 hours. After removal of methanol and tetrahydrofuran by distillation, the aqueous layer was washed with dichloromethane (1 ml), made acidic with conc. hydrochloric acid and extracted with ethyl acetate. The extract was concentrated to remove ethyl acetate to give 2-[4-(6-chloro-2-quinoxalinyloxy)phenoxy]propionic acid (0.44 g). Yield, 76%.

後処理

  1. dissolutionwas dissolved
  2. customwas carried out at room temperature
  3. customAfter removal of methanol and tetrahydrofuran
  4. distillationby distillation
  5. washthe aqueous layer was washed with dichloromethane (1 ml)
  6. extractionextracted with ethyl acetate
  7. concentrationThe extract was concentrated
  8. customto remove ethyl acetate

出典と根拠

ORDレコード
ord-f86923cfcf2f4d39857ee1f34d5789d9
出典データセット
uspto-grants-1992_02
特許番号
US05089043

関連ノート

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