Tetrahydrofuran → 2-((5-amino-7-bromo-3-chloro-1-fluoro-5H-chromeno[2,3-c]pyridin-5-yl)methoxy)acetonitrile

反応式

[Br:27][CH2:28][C:29]#[N:30].[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH3:21][C:22]([CH3:23])([O-:24])[CH3:25].[Li+:26].[NH2:1][C:2]1([CH2:19][OH:20])[c:3]2[cH:4][c:5]([Br:18])[cH:6][cH:7][c:8]2[O:9][c:10]2[c:11]([F:17])[n:12][c:13]([Cl:16])[cH:14][c:15]21>>[NH2:1][C:2]1([CH2:19][O:20][CH2:28][C:29]#[N:30])[c:3]2[cH:4][c:5]([Br:18])[cH:6][cH:7][c:8]2[O:9][c:10]2[c:11]([F:17])[n:12][c:13]([Cl:16])[cH:14][c:15]21