Tetrahydrofuran → 1-[3-(1,3-difluoro-2-methylpropan-2-yl)-1-phenyl-1H-pyrazol-5-yl]-3-[3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]urea

反応式

[CH2:59]1[O:60][CH2:61][CH2:62][CH2:63]1.[CH3:28][O:29][c:30]1[cH:31][c:32]2[c:33]([O:42][c:43]3[cH:44][c:45]([NH2:46])[cH:47][cH:48][cH:49]3)[n:34][cH:35][n:36][c:37]2[cH:38][c:39]1[O:40][CH3:41].[CH:50]([N:51]([CH2:52][CH3:53])[CH:54]([CH3:55])[CH3:56])([CH3:57])[CH3:58].[F:1][CH2:2][C:3]([CH2:4][F:5])([CH3:6])[c:7]1[n:8][n:9](-[c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)[c:10]([NH:12][C:13]([O:14][c:15]2[cH:16][cH:17][cH:18][cH:19][cH:20]2)=[O:21])[cH:11]1>>[F:1][CH2:2][C:3]([CH2:4][F:5])([CH3:6])[c:7]1[n:8][n:9](-[c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)[c:10]([NH:12][C:13](=[O:21])[NH:46][c:45]2[cH:44][c:43]([O:42][c:33]3[c:32]4[cH:31][c:30]([O:29][CH3:28])[c:39]([O:40][CH3:41])[cH:38][c:37]4[n:36][cH:35][n:34]3)[cH:49][cH:48][cH:47]2)[cH:11]1