Dimethylcarbamoyl Chloride → alpha-Diethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acid

HRID 1576250

反応式

HRID 1576250 の反応式
[CH2:1]([N:3]([CH2:7][CH3:8])[C:4](Cl)=[O:5])[CH3:2].C(Cl)(=O)N.C(NC(Cl)=O)C.CN(C)C(Cl)=O.C([S:28][CH:29]([C:33]1[CH:38]=[CH:37][C:36]([CH:39]2[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]2)=[C:35]([Cl:45])[CH:34]=1)[C:30]([OH:32])=[O:31])(=O)N.C(NC(SC(C1C=CC(C2CCCCC2)=C(Cl)C=1)C(O)=O)=O)C.CN(C)C(SC(C1C=CC(C2CCCCC2)=C(Cl)C=1)C(O)=O)=O>>[CH2:1]([N:3]([CH2:7][CH3:8])[C:4]([S:28][CH:29]([C:33]1[CH:38]=[CH:37][C:36]([CH:39]2[CH2:40][CH2:41][CH2:42][CH2:43][CH2:44]2)=[C:35]([Cl:45])[CH:34]=1)[C:30]([OH:32])=[O:31])=[O:5])[CH3:2]

参加物

8

反応物 7

HCID 6598Dimethylcarbamoyl ChlorideHCID 6916Diethylcarbamoyl chlorideHCID 68048Carbamic chlorideHCID 12321963N-ethylcarbamoyl chlorideHCID 21514611alpha-Dimethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acidHCID 21514616alpha-Carbamylthio-3-chloro-4-cyclohexylphenylacetic acidHCID 86733940alpha-Ethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acid

生成物 1

HCID 21514613alpha-Diethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acid

実験手順

When diethylcarbamylchloride is replaced in the above procedure by carbamyl chloride (prepared in situ from potassium cyanate and anhydrous hydrogen chloride in anhydrous chloroform), ethylcarbamyl chloride or dimethylcarbamyl chloride, then the products prepared are α-carbamylthio-3-chloro-4-cyclohexylphenylacetic acid, α-ethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acid or α-dimethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acid.

後処理

  1. customthe products prepared

出典と根拠

ORDレコード
ord-92c1e3e7e8c844cd84ce9c0ca68eed92
出典データセット
uspto-grants-1976_09
特許番号
US03979428

関連ノート

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