Pyrazole → cis-4,6-Diethyl-5-(pyridin-2-ylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine
反応式
[CH2:1]([CH:3]1[CH2:8][C:7](=O)[CH2:6][CH:5]([CH2:10][CH3:11])[N:4]1[S:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1)(=[O:14])=[O:13])[CH3:2].C([C@H]1N[C@@H](CC)CC2(OCCO2)C1)C.Cl.N1C=CC=CC=1S(Cl)(=O)=O.CN(C(OC)OC)C.[NH:54]1[CH:58]=CC=[N:55]1.O.NN>>[CH2:1]([C@H:3]1[C:8]2[CH:58]=[N:54][NH:55][C:7]=2[CH2:6][C@@H:5]([CH2:10][CH3:11])[N:4]1[S:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1)(=[O:14])=[O:13])[CH3:2]参加物
7
反応物 6
生成物 1
実験手順
Prepared by treatment of 2,6-diethyl-1-(pyridin-2-ylsulfonyl)piperidin-4-one, which was prepared by sulfonylation of compound 126 using pyridine-2-sulfonyl chloride hydrochloride followed by deprotection as shown in Example 17, with DMF-DMA followed by pyrazole formation using hydrazine hydrate as shown in Example 15,
出典と根拠
- ORDレコード
- ord-d6e25c829d9240aa83bcc02a7ca1062c
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07732609B2
反応ノート
読み込み中…