Sodium Hydroxide → N-[(4-ethoxyphenyl)methylidene]hydroxylamine

A solution of 34.8 g of hydroxylamine hydrochloride in 50 ml of water was added in one portion to a solution of 37.5 g of 4-ethoxybenzaldehyde in 100 ml of ethanol in a 500-ml Erlenmeyer flask equipped with a magnetic stirrer. The reaction mixture was stirred for approximately 5 minutes, until clear. A room-temperature solution of 15.2 g of sodium hydroxide in 20 ml of water was added in several portions during 15 minutes. The reaction mixture was stirred for 5 minutes and then heated to boiling. After the cloudy reaction mixture had cooled to room temperature, water was added and product separated from solution as an oil. The mixture was extracted four times with 50-ml portions of chloroform. The chloroform extracts were combined, washed twice with 75-ml portions of saturated aqueous sodium chloride solution and dried over sodium sulfate. The dry chloroform solution was filtered, the filtrate was evaporated, and the residue crystallized with a slight amount of cooling. The crude solid was recrystallized from cyclohexane to give 35.4 g of 4-ethoxybenzaldoxime, m.p. 81°-86°. The ir spectrum was consistent with the assigned structure.

1. customequipped with a magnetic stirrer
2. stirringThe reaction mixture was stirred for 5 minutes
3. temperatureheated to boiling
4. customAfter the cloudy reaction mixture
5. customproduct separated from solution as an oil
6. extractionThe mixture was extracted four times with 50-ml portions of chloroform
7. washwashed twice with 75-ml portions of saturated aqueous sodium chloride solution
8. dry with materialdried over sodium sulfate
9. filtrationThe dry chloroform solution was filtered
10. customthe filtrate was evaporated
11. customthe residue crystallized with a slight amount
12. temperatureof cooling
13. customThe crude solid was recrystallized from cyclohexane

ORDレコード

ord-b34b1d4c9bbf4675b4d8cca2b77993be

出典データセット

uspto-grants-1976_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US03983246