Hydrogen Bromide → 3-(Bromomethyl)-1-ethylpyrrolidine
反応式
[CH2:1]([N:3]1[CH2:7][CH2:6][CH:5]([CH2:8]O)[CH2:4]1)[CH3:2].[BrH:10].C(=O)([O-])[O-].[Na+].[Na+]>>[Br:10][CH2:8][CH:5]1[CH2:6][CH2:7][N:3]([CH2:1][CH3:2])[CH2:4]1参加物
4
実験手順
A mixture of 5.0 g. (0.0388 mol.) of N-ethyl-3-hydroxymethylpyrrolidine and 50 ml. of 48% hydrogen bromide was refluxed for 17 hours. The reaction mixture was cooled, made basic by addition of solid sodium carbonate and extracted twice with methylene chloride. The combined extracts were dried (MgSO4) and evaporated to dryness to give 3-bromomethyl-N-ethylpyrrolidine.
後処理
- additionA mixture of 5.0 g
- temperatureThe reaction mixture was cooled
- extractionextracted twice with methylene chloride
- dry with materialThe combined extracts were dried (MgSO4)
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-46401e28484943168e6253f41315513d
- 出典データセット
- uspto-grants-1976_09
- 特許番号
- US03983245
反応ノート
読み込み中…